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Mammalian genome is organized into a highly ordered nucleoprotein complex known as chromatin. Several small modifications both in DNA and protein component of chromatin fine-tune the underlying gene expression programs, genome repair as well as replication and are coined as epigenetic modifications. The alterations in the epigenomic landscape of chromatin are causally related to normal homeostasis of the organism and so as the pathobiological state. The molecular mechanism of epigenetic modification based functions is operated through the protein which recognizes this modification and thereby differentially recruits several other regulatory factors. The research focus of Prof. Chandrima Das group at the Chromatin Dynamics laboratory, SINP is to understand some of these epigenetic readers in the context of cellular functions and their possible connection to the disease, including metabolic as well as infectious diseases.

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TCF19 mediated regulation of MAFLD and its progression to MASH and fibrosis

Epigenetic regulation of ZMYND8 mediated LDHA in the context of tumour immunity in breast cancer

Epigenetic regulation of TCF7l2 mediated MAFLD development in association with T2D

An Atomic Force Microscopy (AFM) based protocol to measure Extra Cellular Matrix (ECM) stiffness

UBR7 mediated epigenetic regulation of interferon beta signaling in Hepatitis B virus infection

Epigenetic regulation TGF beta signaling mediated ECM remodeling by UBR7 in TNBC

Epigentic regulation of sonic hedgehog pathway by ZMYND8 during ATRA mediated nuroblastomal cell differentiation

An Epigenetic metabolic axis of Breast cancer therapy resistance

Epigenetic regulation of T cell in cancer and Immunotherapy

Epigenetic regulation of DNA damage and DNA repair during host-pathogenic interaction

Heartiest congratulations to Prof Chandrima Das, Swagata and Apoorva for getting the review published in Cancer research. That talks about metabolism, DNA damage and cancer drug resistance.

Congratulations to Santanu and Vipin for getting their work on neuronal differentiation by ZMYND8 that regulates MAPT213 LncRNA published in the Journal of Cell Death & Disease.

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033-2337-0221 Ext- 4623

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chandrima.das@saha.ac.in

Chromatin Dynamics Lab

Prof Chandrima Das

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