Thesis Research Summary

Exploring Transcription Regulation by Trans-activating factor 19 (TCF19) in association with tumour suppressor proteins like Tp53 during glucose metabolism. Understanding the role to TCF19 in the context of stress management (varying glucose concentration mediated stress, ER Stress etc.) in HCC

Thesis Research Summary

My research is focused on understanding the role of putative chromatin readers UBR7 and ZMYND8 in regulating cellular oncogenesis and differentiation. My work is focused on elucidating the role of the epigenetic mechanisms involved in modulating EMT, metastasis and therapy resistance in triple-negative breast cancer. I’m also investigating the epigenetic mechanism involved in biogenesis and role of non-coding RNAs in neuronal differentiation.

Thesis Research Summary

My research is focused on understanding the role of two important chromatin reader/effector proteins, Zinc finger MYND-type containing 8 (ZMYND8) and Chromobox 4 (CBX4) in gene expression regulation through distinct epigenetic mechanisms. I have explored the chromatin binding ability of ZMYND8 and its role in ATRA-mediated gene expression regulation. I have also investigated the role of CBX4 in the transcription regulation via modulating the telomerase activity.

Thesis Research Summary

My research is focused to understand the dynamic role of chromatin reader Speckled 110 (Sp110), a PML-NB resident protein in transcription regulation, in a chromatin context-dependent manner. Towards that I have elucidated a a new mechanism in which the HBV hijacks a host protein Sp110 and exploits its chromatin binding property to evade the host immune-response and promote viral pathogenesis. I have also explored the role of Sp110 in metabolic gene expression regulation implicated in cellular migration and invasion leading to HBV-induced Hepatocellular Carcinoma.

Thesis Research Summary

My research is focused on understanding the role of the role of chromatin reader Transcription Factor 19 (TCF19) in modulating the epigenetic programs of metabolic genes upon high glucose stimulation. I have explored the chromatin-binding property of the protein and its consequent functional regulation in the context of expression of the gluconeogenic genes. I have also investigated the association of TCF19 with Transcription Factor 7 like 2 (TCF7l2), another key transcription controller of metabolic genes in ER stress.

The preliminary aim of this work is to delineate the differences in the metabolic landscape in different cell types residing in the core and peripheral tumor regions of the tumor mass by performing transcriptomic and metabolomic analysis. The study also intends to unravel the key epigenetic signatures and regulatory mechanism behind these altered metabolic pathways in the core and the peripheral tumor cells.

Investigating the role of epigenetic modulators in the progression of Hepatitis B virus (HBV) infection and consequent regulation of DNA damage response pathways

Understanding the role of ZF transcription factor, ZMYND8 in suppressing the EMT, MDR and CSC genes maintained in a poised epigenetic state. Exploring the mechanism of promoting the cancer cell differentiation program by ZMYND8.

Understanding the role of ZF transcription factor, ZMYND8 as a regulator of tumorigenicity by augmenting epithelial gene expression program. Further the role of ZMYND8 in modulating retinoid-based therapy (as an All trans retinoic acid-responsive transcription factor) has also been investigated.